Anne or Ann Smith may refer to:
Arts and media
Ann Smith Franklin (born Ann Smith, 1696–1763), American newspaper printer and publisher
Anne Smith (silversmith) (fl. 1771–1782), English silversmith
Ann Eliza Smith (1819–1905), American author and patriot
Anne Smith (fl. 1955), actress in The Time of His Life
Anne Easter Smith, British-American novelist
Anne Mollegen Smith, American magazine editor and writer
Ann Lesley Smith (born 1956), American journalist
Sport
Anne Smith (runner) (1941–1993), British middle-distance runner
Anne Smith (footballer) (born 1951), New Zealand footballer
Anne Smith (tennis) (born 1959), American tennis player
Other fields
Ann Smith (activist) (fl. 1682–1686), English anti-Catholic political activist
Lady Anne Culling Smith (1775–1844), sister of Arthur Wellesley, 1st Duke of Wellington
Dame Anne Beadsmore Smith (1869–1960), British Army nurse
Anne Ripley Smith (1881–1949), co-founder of Alcoholics Anonymous
Anne Abel Smith (born 1932), British aristocrat and charity volunteer
Anne Smith (academic) (1940–2016), New Zealand children's rights researcher
Ann Alexander Smith (born 1947), Louisiana educator
Anne Smith, Lady Smith (born 1955), Scottish Supreme Court judge
Fictional characters
Ann Smith, a character in Mr. & Mrs. Smith