Santa Croce is Italian for 'Holy Cross' and may refer to:
Santa Croce (Venice), one of the six sestieri (districts) of Venice, Italy.
The Pontifical University of the Holy Cross (Italian: Pontificia Università della Santa Croce) in Rome, Italy.
Many churches, including:
Santa Croce, Florence, built 1294–1385 and the burial place of several notable Italians
Santa Croce della Foce, Gubbio, Umbria, built in the 13th century
Basilica di Santa Croce (Lecce), built 1549–1646
Santa Croce, Parma, built 1222–1666
Santa Croce, Padua, built 1737–1749
Santa Croce in Fossabanda, Pisa, built 1325–19th century
Santa Croce e San Bonaventura alla Pilotta, Rome, built 1625–19th century
Santa Croce in Gerusalemme, Rome, consecrated around 325
Santa Croce alla Lungara, Rome, consecrated 1619
Santa Croce degli Armeni, Venice, built 13th century, consecrated 1688
Santa Croce in Via Flaminia, Rome, built 1913, consecrated 1981
People
House of Santacroce, a noble Roman family. To this belongs among others:
Prospero Santacroce, 16th-century cardinal
Cecilia Santacroce (born 1990), Italian archer
Fabiano Santacroce (born 1986), Italian-Brazilian football player
Isabella Santacroce (born 1970), Italian novelist
Girolamo Santacroce, a 16th-century Italian sculptor and painter
Places
Santa Croce sull'Arno, town in Tuscany
Santa Croce Camerina, town in Sicily
Villages
Santa Croce di Magliano, a commune in Campobasso, Molise
Santa Croce di Roccaromana, a commune in Caserta, Campania
Santa Croce del Sannio, a commune in Benevento, Campania