Matthew Ryan may refer to:
Arts and entertainment
Matthew Ryan (musician) (born 1971), American musician
Matthew Ryan (writer), Australian playwright, theatre director and screenwriter
Matt Ryan (actor) (born 1981), Welsh actor
Matt Ryan, character from the Australian TV series City Homicide
Matthew Abraham Ryan (Abram Joseph Ryan), American Catholic poet, priest, journalist, orator
Politics
Matthew Ryan (politician) (1810–1888), Stipendiary Magistrate on the 1st Council of the Northwest Territories
Matthew J. Ryan (1932–2003), U.S. politician from Pennsylvania
Sports
Rugby league
Matthew Ryan (rugby league) (born 1969), Australian rugby league footballer
Mat Ryan (rugby league) (1913–1994), Australian rugby league player
Matt Ryan (rugby league) (born 1988), Australian rugby league footballer
Other sports
Matthew Ryan (equestrian) (born 1964), Australian equestrian
Matthew Ryan (handballer) (born 1966), Olympic handball captain
Matthew Ryan (Australian rules footballer) (born 1967)
Matt Ryan (ice hockey) (born 1983), Canadian ice hockey player
Matt Ryan (rower) (born 1984), Australian rower
Matt Ryan (American football) (born 1985), American football player and executive
Mathew Ryan (born 1992), Australian soccer goalkeeper
Matt Ryan (basketball) (born 1997), American basketball player
Matt Ryan (rugby union) (born 1967), Australian rugby union player