John Wolfe may refer to:

John Wolfe (printer) (1548?–1601), English bookseller and printer

John Wolfe, 2nd Viscount Kilwarden (1769–1830), Irish peer

Jack A. Wolfe (1936–2005), American paleontologist

John Bascom Wolfe (1904–1988), American social and behavioral psychologist

John Clay Wolfe (born 1972), American radio personality and entrepreneur

John Wolfe Jr. (born 1954), Tennessee politician

John P. Wolfe (born 1970), American chemist

John Richard Wolfe (1832-1915), Irish missionary who served in China

John Thomas Wolfe (1955–1995), veterinarian and Canadian provincial politician

John T. Wolfe Jr. (born 1942), president of Savannah State College

John Wolfe (priest), Irish Anglican priest

John Wolfe (rugby union), Australian international rugby union player