John Wolfe may refer to:
John Wolfe (printer) (1548?–1601), English bookseller and printer
John Wolfe, 2nd Viscount Kilwarden (1769–1830), Irish peer
Jack A. Wolfe (1936–2005), American paleontologist
John Bascom Wolfe (1904–1988), American social and behavioral psychologist
John Clay Wolfe (born 1972), American radio personality and entrepreneur
John Wolfe Jr. (born 1954), Tennessee politician
John P. Wolfe (born 1970), American chemist
John Richard Wolfe (1832-1915), Irish missionary who served in China
John Thomas Wolfe (1955–1995), veterinarian and Canadian provincial politician
John T. Wolfe Jr. (born 1942), president of Savannah State College
John Wolfe (priest), Irish Anglican priest
John Wolfe (rugby union), Australian international rugby union player