James Tyler may refer to:

James Tyler (bobsleigh) (born 1960), American Olympic bobsledder

James Tyler (musician) (1940–2010), American lutenist and early music researcher

James Endell Tyler (1789–1851), Anglican minister, historian and theologian

James Hoge Tyler (1846–1925), American politician and governor of Virginia

James Hoge Tyler III (1910–1988), his grandson, American attorney and member of the Virginia Senate

James Manning Tyler (1835–1926), United States Representative from Vermont

James Michael Tyler (1962–2021), American actor

James Tyler Guitars, electric guitar manufacturer in California