James Andrew may refer to:

James Andrew (MP) (fl. 1410), MP for Ipswich

James Osgood Andrew (1794–1871), American Bishop of the Methodist Episcopal Church and the Methodist Episcopal Church, South

James Andrew (educator) (c. 1774–1833), Principal of the East India Military College at Croydon

James Andrew (physician) (1829–1897), English physician, Fellow of the Royal College of Physicians