Great Southern may refer to:

Great Southern (automobile), a car in production from 1910 to 1914

Great Southern (band), the backing band for American rock guitarist Dickey Betts

Great Southern (train), a luxury train service in Australia

Great Southern (Western Australia), a region in Western Australia

Great Southern (wine region), in Western Australia

Great Southern Group, a corporate group in Australia which collapsed in 2009

Great Southern Television, based in Auckland and Sydney

TSS Great Southern (1902), a ship built in 1902 for the Great Western Railway

Great Southern Bank, Australian bank