First Look could refer to:

1st Look, a weekly late-night NBC series about urban culture and food

First Look Media, a news organization

First-look deal, a deal with a production company to get a first look at a project

Morning Joe First Look, a news program on MSNBC; formerly solely titled First Look

First Look Film Festival (MoMI), annual festival by the Museum of the Moving Image

First Look Film Festival, former annual festival in Denver