First Look could refer to:
1st Look, a weekly late-night NBC series about urban culture and food
First Look Media, a news organization
First-look deal, a deal with a production company to get a first look at a project
Morning Joe First Look, a news program on MSNBC; formerly solely titled First Look
First Look Film Festival (MoMI), annual festival by the Museum of the Moving Image
First Look Film Festival, former annual festival in Denver