First Kill may refer to:

First Kill (2017 film), an American film

First Kill (compilation), a 1986 compilation album by Tygers Of Pan Tang

First Kill (2001 film), a Dutch documentary film

"First Kill", a song by Amon Amarth on the 2016 album Jomsviking

"Chuck Versus the First Kill", a 2009 episode of Chuck

First Kill (TV series), a 2022 supernatural teen drama television series