Eastern Macedonia most commonly refers to the western part of Eastern Macedonia and Thrace, in Greece.
It may also refer to:
eastern parts of the wider geographical and historical region of Macedonia
Pirin Macedonia, the part of the region of Macedonia in Bulgaria
Eastern Statistical Region, a statistical region in modern North Macedonia
eastern parts of the ancient Kingdom of Macedonia
eastern parts of the ancient Roman Province of Macedonia
Eastern Macedonia Army Section, an army group of the Hellenic Army in World War II
Technological Educational Institute of Eastern Macedonia and Thrace, an institute in Kavala, Greece