Diana Frances or Diana Francis may refer to:

Diana Frances Spencer (1961–1997), better known as Diana, Princess of Wales

Diane de France (1538–1619), daughter of French king Henry II

Diana Frances (comedian) (fl. 1990s–2020s), Canadian comedian, writer, and business manager

Diana Francis (peace activist) (born 1944), British peace activist and scholar

Diana Pharaoh Francis (born c. 1967), American professor and fantasy novelist

Diane Francis (born 1946), Canadian journalist

Diane Francis (sprinter) (born 1968), Saint Kitts and Nevis sprinter