De Soto commonly refers to
Hernando de Soto (c. 1500 – 1542), Spanish explorer
DeSoto (automobile), an American automobile brand from 1928 to 1961
De Soto, DeSoto, Desoto, or de Soto may also refer to:
Places in the United States of America
Populated places
De Soto, Georgia
De Soto, Illinois
De Soto, Iowa
De Soto, Kansas
De Soto, Mississippi
De Soto, Missouri
De Soto, Nebraska
De Soto, Wisconsin
DeSoto, Indiana
DeSoto, Texas, the most populous De Soto in the US
Administrative divisions
De Soto Parish, Louisiana
DeSoto County, Florida
DeSoto County, Mississippi
Parks and geographic features
De Soto National Forest in Mississippi
DeSoto Falls (Alabama)
DeSoto Falls (Georgia)
DeSoto Lake, a lake in Georgia
DeSoto National Wildlife Refuge, in Nebraska and Iowa
Fort De Soto Park in St. Petersburg, Florida
De Soto National Memorial in Bradenton, Florida
DeSoto Site Historic State Park in Tallahassee, Florida
People
de Soto (surname)
Other uses
The DeSoto, historic hotel in Savannah, Georgia
DESOTO patrols, conducted by the U.S. Navy to collect signals intelligence in hostile waters
DeSoto Records, a record label
USS De Soto County (LST-1171), a post-war Landing Ship Tank of the US Navy
De Soto station, Los Angeles
De Soto Avenue, Los Angeles