Charles Spencer may refer to:
Nobility
Charles Spencer, 3rd Earl of Sunderland (1675–1722), English statesman
Charles Spencer, 3rd Duke of Marlborough (1706–1758), British soldier and politician
Lord Charles Spencer (1740–1820), 2nd son of the 3rd Duke of Marlborough
Charles Spencer, 6th Earl Spencer (1857–1922), British courtier and Liberal politician
Charles Spencer, 9th Earl Spencer (born 1964), brother of Diana, Princess of Wales
Sports
Charles Spencer (cricketer) (1903–1941), Welsh cricketer
Charlie Spencer (1899–1953), England and Newcastle United footballer
Charles Spencer (American football) (born 1982), American football player
Tony Mamaluke (born 1977), American professional wrestler a.k.a. Charles John Spencer
Others
Charles A. Spencer (1813–1881), American scientific pioneer and inventor
Charles Nichols Spencer (1837–1893), Hawaiian businessman and politician
Cosens Spencer (1874–1930), known posthumously as Charles Cozens Spencer, British-born Canadian film exhibitor and producer in Australia
Charles S. Spencer (born 1950), American curator, researcher, and anthropologist
Charles Spencer (journalist) (born 1955), British journalist and longstanding drama critic of the Daily Telegraph
Charles Spencer (pianist) (born 1955), English classical pianist and music educator
Charles Green Spencerr (1837–1890), pioneer aviator who founded the balloon manufacturing company C. G. Spencer & Sons
Charles Spencer (Neighbours), fictional character on Australian soap Neighbours
Other uses
Charles H. Spencer hulk, a 1912 steamboat that ran on the Colorado River
Charles R. Spencer, a 1901 steamboat that ran on the Columbia and Willamette Rivers