Charles Louis may refer to:
Nobility:
Charles I Louis, Elector Palatine (1617–1680)
Charles Louis Auguste Fouquet, duc de Belle-Isle (1684–1761), French general and statesman
Duke Charles Louis Frederick of Mecklenburg (1708–1752), father of Queen Charlotte of the United Kingdom
Charles Louis, Hereditary Prince of Baden (1755–1801)
Charles Louis Huguet, marquis de Sémonville (1759–1839), French diplomat and politician
Napoleon III, formerly Charles Louis Napoléon Bonaparte (1808–1873), 1st President of France, later Emperor of the French
Charles Auguste Louis Joseph, duc de Morny (1811–1865), French statesman
Archduke Karl Ludwig of Austria (1833–1896), father of Archduke Franz Ferdinand of Austria
Archduke Carl Ludwig of Austria (1918–2007)
Charles-Louis, duc de Chartres (born 1972)
Other people:
Charles-Louis Richard (1711–1794), Catholic theologian
Charles-Louis Clérisseau (1721–1820), French architectural draughtsman
Charles Louis L'Héritier de Brutelle (1746–1800), French botanist and magistrate
Charles-Louis de Fourcroy (born 1766), French Consul at A Coruña
Antoine Charles Louis Lasalle (1775–1809), French cavalry General during the Revolutionary and Napoleonic Wars
Charles-Louis Havas (1783–1858), French writer and founder of the news agency Agence France-Presse (AFP)
Charles-Louis Hanon (1819–1900), French piano pedagogue and composer
Charles Louis Kincannon (born 1940), former director of the United States Census Bureau
Charles-Louis Seck (born 1965), retired Senegalese athlete