Charles James may refer to:
Charles James (British Army officer) (1757/8–1821), English army officer and writer
Charles James (attorney) (born 1954), former U.S. assistant attorney general
Charles James (American football) (born 1990), American football cornerback
Charlie James (baseball) (born 1937), baseball player
Charles James (chemist) (1880–1928), discoverer of lutetium
Charles James (designer) (1906–1978), fashion designer
Charlie James (footballer) (1874–1948), Australian rules footballer
Charles James (footballer) (1882–1960), footballer for Stoke
Charles James (MP) (1817–1890), British politician
Charles James (rugby league) (1891–1917), New Zealand rugby league footballer
Charles C. James (1882–1957), American consulting accountant
Charlie Hamilton James (born c. 1974), English photographer, television cameraman and presenter
Charles Holloway James (1893–1953), architect
Charles O. James, Texas state senator, 1899–1903; state representative, 1893–1895, see Texas Senate, District 2
Charles Pinckney James (1818–1899), U.S. federal judge
Charles Tillinghast James (1805–1862), U.S. Senator from Rhode Island
Chuck James (born 1981), baseball player
Charles James (cricketer) (1885–1950), English cricketer
Captain Charles James, fictional character from Our Girl