Big One, or The Big One may refer to:
Disasters
The Big One, describing an anticipated megathrust earthquake along Western North America, the Philippines, or Japan
Nankai megathrust earthquakes
Cascadia subduction zone#Megathrust earthquakes
San Andreas Fault#The next "Big One"
Marikina Valley fault system#Threat
Films, stories and popular culture
The Big One, a 1995 TV film starring Rik Mayall
The Big One (film), a 1998 film by Michael Moore
The Big One, a 2005 film starring Yangzom Brauen
The Big One: the Story of TGR's 16 Years in Jackson Hole, a 2006 ski documentary by Teton Gravity Research
The Big One (TV series), an early-1990s comedy series starring Sandi Toksvig and Mike McShane
"The Big One" (Gilmore Girls), a third-season episode of the television series Gilmore Girls
"The Big One" (Dexter), a 2010 episode of the television series Dexter
The Big One: The Great Los Angeles Earthquake, a 1990 made-for-television movie starring Joanna Kerns, depicting a massive earthquake that destroys Los Angeles, California
Sōkichi Bamba/Big One, a fictional character in J.A.K.Q. Dengekitai
"The Big One", the fake heart attack that Redd Foxx would regularly have on the television series Sanford and Son
Big One, a locomotive from the anime series The Galaxy Railways
The Big One (roller coaster), a roller coaster in Blackpool Pleasure Beach
"The Big One", the nickname given to Red Nose Day 2007, a fundraising event held in the UK organised by Comic Relief
"The Big One", a slogan used by WLW 700 AM, a radio station in Cincinnati, Ohio
The Big One (motorsport), phrase describing a crash usually involving five or more cars in stock car racing
Big One for One Drop, a poker tournament featuring the largest buy-in events
”The Big One”, nickname of the Big Score, the final heist mission in Grand Theft Auto V.
The Big One, a 2023 protest by activist group Extinction Rebellion
Global conflicts
“The Big One” — World War II
Music
Albums
The Big One (Daddy Freddy album), a 1994 album by ragga vocalist Daddy Freddy
Big Ones (Aerosmith album), a 1994 compilation album by Aerosmith
Big Ones (Loverboy album), a 1989 compilation album by Loverboy
The Big One (Rayvanny album), a 2024 album by Tanzanian singer Rayvanny
Songs
"Big One", single by Judge Dread, Lemon, Hughes 1973
"The Big One (George Strait song)", 1994
The Big One (Black song), 1988
"The Big One", a song by Nellie McKay from her album Pretty Little Head
"The Big One", a 1998 single by Confederate Railroad
"The Big One", an instrumental theme by Alan Tew used in The People's Court television show