Iowa is a landlocked state in the upper Midwestern region of the United States. It borders the Mississippi River to the east and the Missouri River and Big Sioux River to the west; Wisconsin to the northeast, Illinois to the east and southeast, Missouri to the south, Nebraska to the west, South Dakota to the northwest, and Minnesota to the north. Iowa is the 26th largest in total area and the 31st most populous of the 50 U.S. states, with a population of 3.19 million. The state's capital, most populous city, and largest metropolitan area fully located within the state is Des Moines.