Alexander or Alex Henderson may refer to:
Alexander Henderson (theologian) (c. 1583–1646), Scottish theologian
Alexander Henderson (American politician) (1738–1815), Scottish merchant and politician in Virginia
Alexander Henderson of Press (c. 1770–1826), Lord Provost of Edinburgh, 1823–1825
Alexander Henderson (physician) (1780–1863), Scottish physician, author of History of Ancient and Modern Wines (1824)
Alexander Henderson (priest) (1807–1888), Scottish Episcopalian priest, Dean of Glasgow and Galloway
Alexander Henderson, 1st Baron Faringdon (1850–1934), British politician
Alexander Henderson (Canadian politician) (1860–1940), historical member of the Legislative Assembly of British Columbia, and Commissioner of Yukon 1907–1911
Alexander D. Henderson Jr. (1895–1964), American businessman
Alex Henderson (Scottish footballer) (1800s), Scottish footballer
Alexander Gavin Henderson, 2nd Baron Faringdon (1902–1977), British Labour politician
Alex Henderson (footballer, born 2001), English footballer
Alex Henderson (footballer, born 2004), English footballer
Alex Henderson (runner), winner of the 1958 NCAA two-mile run championship
Alex Henderson (bowls), Scottish bowls player
Alex Henderson, band member of Big Bad Voodoo Daddy.